Metalloproteinase domain structure, cellular invasion and metastasis.

نویسندگان

  • M I Cockett
  • M L Birch
  • G Murphy
  • I R Hart
  • A J Docherty
چکیده

18. Crook, T. and Vousden, K. H. (1992) EMBO J. 11, 3935-3940 19. Finlay, C. A., Hinds, P. W. and Levine, A. J. (1989) Cell 57,1083-1093 20. Farmer, G., Bargonetti, J., Zhu, H., Friedman, P., Prywes, R. and Prives, C. (1992) Nature (London) 358,83-86 21. Ginsberg, D., Mechta, F., Yaniv, M. and Oren, M. (1991) Proc. Natl. Acad. Sci. U.S.A. 88,9979-9983 22. Kastan, M. B., Onyekwere, O., Sidransky, D., Vogelstein, H. and Craig, R. W. (1991) Cancer Res. 51, 6304-63 1 1 23. Reference deleted. 24. Lane, D. P. and Crawford, L. V. (1979) Nature (London) 278,6 1-63 25. Hubbert, N. L., Sedman, S. A. and Schiller, J. T. (1992) J. Virol. 66,6237-6241 26. Scheffner, M., Werness, B. A., Huibregtse, J. M., Levine, A. J. and Howley, P. M. (1990) Cell 63, 1129-1 136 27. Reference deleted. 55 28. Finley, D. and Chau, V. (199 1) Annu. Rev. Cell Biol.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Matrix Metalloproteinase Expression Significance on Oral squamous cell carcinoma Clinical Outcome

Introduction:Oral Squamous Cell Carcinoma (OSCC) is an invasive neoplasm with a high prevalence. Matrix Metalloproteinase (MMP) has been thought to play an important role in both the invasion and metastasis of tumors. The aim of this study was to explore the significance of MMPs expression in clinical outcome of these patients. Materials:The most recognized data Bases such as PubMed, Google sc...

متن کامل

Study of Antimetastatic Effect of Genistein Through Inhibition of Expression of Matrix Metalloproteinase in A-549 Cell Line

The lung cancer is one of the most dangerous cancers and is also the leading cause of cancer death worldwide, accounting for about 1.3 million deaths annually. However in clinical practice, lung cancer therapies commonly do with chemotherapy, although it is hard because the lung cancer may progress to metastasis stage. The metastasis of lung cancer is highly dependent of expression of matrix me...

متن کامل

MMP-2, TIMP-2 and CD44v6 expression in non-small-cell lung carcinomas.

INTRODUCTION Factors that emerge as crucial participants in tumour invasion and metastases are matrix metalloproteinases (MMPs), tissue inhibitor of metalloproteinase (TIMP) inhibitors and cellular adhesion molecules (CD44 and similar molecules). They play important roles in tumour invasion and metastasis in non-small-cell lung carcinomas (NSCLCs). MATERIALS AND METHODS The study was performe...

متن کامل

Development of a specific affinity-matured exosite inhibitor to MT1-MMP that efficiently inhibits tumor cell invasion in vitro and metastasis in vivo

The membrane-associated matrix metalloproteinase-14, MT1-MMP, has been implicated in pericellular proteolysis with an important role in cellular invasion of collagenous tissues. It is substantially upregulated in various cancers and rheumatoid arthritis, and has been considered as a potential therapeutic target. Here, we report the identification of antibody fragments to MT1-MMP that potently a...

متن کامل

N-myc downstream regulated gene 2 overexpression reduces matrix metalloproteinase-2 and -9 activities and cell invasion of A549 lung cancer cell line in vitro

Objective(s):N-myc downstream regulated gene 2 (NDRG2) is a candidate gene for tumor suppression. The expression of NDRG2 is down-regulated in several tumors including lung cancer. The aim of this study was to explore the effect of NDRG2 overexpression on invasion, migration, and enzymatic activity of matrix metalloproteinase-2 (MMP-2) and -9 (MMP-9) in human lung adenocarcinoma A549 cells.  Ma...

متن کامل

A Case-Control Study of Comparison of Plasma Levels of Matrix Metalloproteinase-9 in Inhaled Opium Addicts and Clinically Healthy Persons

cancer invasion and lymphatic metastasis. Smoking has been reported to increase the metalloproteinase level, but the role of opium consumption in metalloproteinase level has not yet been examined. The current research intended to examine the impacts of opium consumption on the serum levels of metalloproteinase.Methods: This case-control research was conducted in Kerman (in the southeast of Iran...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Biochemical Society transactions

دوره 22 1  شماره 

صفحات  -

تاریخ انتشار 1994